Intradiscal Injection of O2-O3 to Treat Lumbar Disc Herniations Results at Five Years

A method allowing shrinkage of a herniated disc, without an open surgical approach has long been sought. Studies on the spontaneous disappearance of disc fragments have demonstrated autoimmune responses with a chronic inflammatory reaction, and radicular pain has been shown to be mostly due to release of toxic acids . Researchers in different fields surprisingly noted that a short, calculated, oxidative stress by ozone administration may correct a persistent imbalance due to excessive chronic oxidative injury . Oxygen-ozone gas injection in patients with pain has a dramatic effect on clinical symptoms. On these bases the intradiscal injection of oxygen-ozone gas was conceived .We report the treatment of 6665 patients with disc pathology by intradiscal injection of an oxygen-ozone gas mixture. The effect on pain and radicular dysfunction was dramatic. The effect of the treatment has also been evaluated by pathological examination.